The first difference is that Excel does not load any add-ins in safe mode. There are some fundamental differences between the safe mode and the normal mode of Excel in terms of their activities, and features.
Read More: How to Run Excel in Safe Mode (4 Handy Ways)ĥ Specific Differences Between Excel Safe Mode and Normal Mode
Excel will open a workbook in safe mode. Then type excel /safe in the box and press OK. To open Excel in safe mode, press Windows + R keys to launch the Run. When an app crashes and you can’t open files in regular mode, or when you want to check if an add-in or extension might be causing a problem upon starting, Safe Mode might be helpful. Office applications can operate in a special mode called “ safe mode” when something isn’t working properly. 
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